Effects of pre-analytical processes on blood samples used in metabolomics studies
نویسندگان
چکیده
منابع مشابه
Effects of pre-analytical processes on blood samples used in metabolomics studies
Every day, analytical and bio-analytical chemists make sustained efforts to improve the sensitivity, specificity, robustness, and reproducibility of their methods. Especially in targeted and non-targeted profiling approaches, including metabolomics analysis, these objectives are not easy to achieve; however, robust and reproducible measurements and low coefficients of variation (CV) are crucial...
متن کاملSPIDIA-RNA: first external quality assessment for the pre-analytical phase of blood samples used for RNA based analyses.
The diagnostic use of in vitro molecular assays can be limited by the lack of guidelines for collection, handling, stabilization and storage of patient specimens. One of the major goals of the EC funded project SPIDIA (www.spidia.eu) is to develop evidence-based quality guidelines for the pre-analytical phase of blood samples used for molecular testing which requires intracellular RNA analytes....
متن کاملSPIDIA-RNA: Second External Quality Assessment for the Pre-Analytical Phase of Blood Samples Used for RNA Based Analyses
One purpose of the EC funded project, SPIDIA, is to develop evidence-based quality guidelines for the pre-analytical handling of blood samples for RNA molecular testing. To this end, two pan-European External Quality Assessments (EQAs) were implemented. Here we report the results of the second SPIDIA-RNA EQA. This second study included modifications in the protocol related to the blood collecti...
متن کاملImpact of Pre-analytic Blood Sample Collection Factors on Metabolomics.
BACKGROUND Many epidemiologic studies are using metabolomics to discover markers of carcinogenesis. However, limited data are available on the influence of pre-analytic blood collection factors on metabolite measurement. METHODS We quantified 166 metabolites in archived plasma from 423 Health Professionals Follow-up Study and Nurses' Health Study participants using liquid chromatography-tande...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2015
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-015-8565-x